ResearchDx
YOUR COMPANION IN DIAGNOSTICS ®
ResearchDx
  • BIOPHARMA SERVICES
    • BioPharma Services
    • Biorepository Services
    • Biomarker Discovery & Validation
    • Exosome Isolation and Analysis
    • Liquid Biopsy Cancer Screening
    • Flow Cytometry Services
    • PCR, QPCR, RT-QPCR and ddPCR
    • Next Generation Sequencing Services
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ResearchDx Capabilities

Technical Capabilities

We support diverse sequencing and genomic technologies for use in IVD diagnostics development in the fields of oncology, infectious diseases, and heritable diseases. If you are looking for a specific technology not found below, please contact us

Next Generation Sequencing

Roche 

Avenio Targeted Panel: This allows for the analysis of 17 oncology related genes, including those published in the National Comprehensive Cancer Network (NCCN) guidelines.

Avenio Expanded Panel:  The expanded panel includes the 17 NCCN guideline related genes as well as 60 additional biomarkers that are currently being analyzed in oncology clinical trials to determine their utility

Avenio Surveillance Panel:  True to its name the surveillance panel has been optimized with the guideline genes as well as 180 additional genes to allow for longitudinal analysis that monitors tumor burden (TMB) and minimal residual disease (MRD).

Illumina

The TruSight Oncology (TSO) 500 panel:  The TSO panel is designed for the SNV, Indel, CNV and fusion analysis of 523 oncology related genes making it a great biomarker discovery tool. It also analyzes Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI). 

Quantitative Real-Time PCR (qRTPCR)

  • Gene expression
  • Copy number variation
  • Absolute copy number variation (CNV)
  • Confirmatory testing
  • SNP genotyping and allelic discrimination
  • Methylation analysis (CpG)
  • Pathogen detection and quality control
  • Rare mutation and allelic discrimination
  • Low-abundance transcript detection
  • Viral titer (copies/mL)
  • Vector copy number (copies/genome)
  • Circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA) detection in liquid biopsy

ddPCR

  • Rare sequence and mutation detection
  • NGS pre- and post-run validation
  • Sensitive copy number variation (CNV) detection
  • Viral titer (copies/mL)
  • Qualification of Nucleic acids
  • Single-cell analysis
  • Gene editing event detection
  • Gene expression and miRNA analysis
  • Liquid biopsy: cfDNA
  • Biodistribution in including Gene therapy vectors

FISH: RNA or DNA

  • All commercially available probes
  • Custom probe design and manufacture
  • RUO, IUO, and GMP manufacture


Cell & Tissue Methodologies

We support anatomic pathology, liquid cell sorting and enrichment, and cytogenetics techniques deployed for various applications, particularly oncology.

Flow Cytometry

  • Commercial and custom flow panel for hematology and lymphoid malignancies
  • Biomarker detection
  • Cell-profiling / Immunophenotyping Immunophenotyping
  • Receptor Occupancy Assay
  • Rare Cell Detection and Quantification
  • Intracellular Cytokine Staining (ICS)
  • Phosphoflow Assay
  • CAR-T Characterization
ResearchDx Flow Cytometry Services CytoFLEX S V0-B4-R3-I2 Flow Cytometer

Cell Sorting & Enrichment

  • Fluorescence-Activated Cell Sorting (FACS)
  • Individual tumor and stromal cell recovery from FFPE and CTC samples

Anatomic Pathology

  • Metasystems Metafer imaging station
  • Carl Zeiss Auto Imager
  • IHC, H&E on FFPE and Frozen tissue
  • Pathology review and macro-dissection

Cell Culture

  • 100+ characterized control cell lines for oncology applications
  • FFPE control cell block preparation
  • Control DNA/RNA preparation


Support Technologies

We support diverse technologies for IVD development and scale-up activities that may require automated DNA extraction and liquid-handling systems.

ELISA (Immunoassay)

  • Direct and Sandwich ELISA
  • Identify and qualify commercial fit for purpose ELISA kits for PK & PD studies
  • Wide applicability for assay development
  • Analyte detection e.g., cytokines

EXO-NET® Pan-Exosome Capture

EXO-NET® Pan-Exosome Capture is an immunoaffinity magnetic bead-based isolation system for exosome isolation from plasma, serum, urine, saliva and cell-conditioned medium. 

EXO-NET is the highest-efficiency exosome isolation solution available

EXO-NET is Compatible for use with the following downstream applications:

  • NGS
  • qPCR
  • Mass Spec
  • ELISA
  • FTIR
  • FACs

 

 

Automation

  • Hamilton Star, Microlab Star
  • QIACube®
  • QIASymphony® SP
  • Scale-up applications

To discuss your individual project needs, please contact us. 

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