Technical Capabilities

Roche 

Avenio Targeted Panel: This allows for the analysis of 17 oncology related genes, including those published in the National Comprehensive Cancer Network (NCCN) guidelines.

Avenio Expanded Panel:  The expanded panel includes the 17 NCCN guideline related genes as well as 60 additional biomarkers that are currently being analyzed in oncology clinical trials to determine their utility

Avenio Surveillance Panel:  True to its name the surveillance panel has been optimized with the guideline genes as well as 180 additional genes to allow for longitudinal analysis that monitors tumor burden (TMB) and minimal residual disease (MRD).

Illumina

The TruSight Oncology (TSO) 500 panel:  The TSO panel is designed for the SNV, Indel, CNV and fusion analysis of 523 oncology related genes making it a great biomarker discovery tool. It also analyzes Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI). 

• Gene expression
• Copy number variation
• Absolute copy number variation (CNV)
• Confirmatory testing
• SNP genotyping and allelic discrimination
• Methylation analysis (CpG)
• Pathogen detection and quality control
• Rare mutation and allelic discrimination
• Low-abundance transcript detection
• Viral titer (copies/mL)
• Vector copy number (copies/genome)
• Circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA) detection in liquid biopsy

• Rare sequence and mutation detection
• NGS pre- and post-run validation
• Sensitive copy number variation (CNV) detection
• Viral titer (copies/mL)
• Qualification of Nucleic acids
• Single-cell analysis
• Gene editing event detection
• Gene expression and miRNA analysis
• Liquid biopsy: cfDNA
• Biodistribution in including Gene therapy vectors

• All commercially available probes
• Custom probe design and manufacture
• RUO, IUO, and GMP manufacture

• Commercial and custom flow panel for hematology and lymphoid malignancies
• Biomarker detection
• Cell-profiling / Immunophenotyping Immunophenotyping
• Receptor Occupancy Assay
• Rare Cell Detection and Quantification
• Intracellular Cytokine Staining (ICS)
• Phosphoflow Assay
• CAR-T Characterization

• Fluorescence-Activated Cell Sorting (FACS)
• Individual tumor and stromal cell recovery from FFPE and CTC samples

• Metasystems Metafer imaging station
• Carl Zeiss Auto Imager
• IHC, H&E on FFPE and Frozen tissue
• Pathology review and macro-dissection

• 100+ characterized control cell lines for oncology applications
• FFPE control cell block preparation
• Control DNA/RNA preparation

• Direct and Sandwich ELISA
• Identify and qualify commercial fit for purpose ELISA kits for PK & PD studies
• Wide applicability for assay development
• Analyte detection e.g., cytokines

EXO-NET^® Pan-Exosome Capture is an immunoaffinity magnetic bead-based isolation system for exosome isolation from plasma, serum, urine, saliva and cell-conditioned medium. 

EXO-NET is the highest-efficiency exosome isolation solution available

EXO-NET is Compatible for use with the following downstream applications:

• NGS
• qPCR
• Mass Spec
• ELISA
• FTIR
• FACs

• Hamilton Star, Microlab Star
• QIACube®
• QIASymphony® SP
• Scale-up applications