Next Generation Sequencing Services

Highlights of Targeted Panel, Exome & Genome Sequencing Services

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Roche Avenio Validated Panels

The Targeted Panel:
This allows for the analysis of 17 oncology-related genes, including those published in the National Comprehensive Cancer Network (NCCN) guidelines.

The Expanded Panel:
The expanded panel includes the 17 NCCN guideline-related genes as well as 60 additional biomarkers that are currently being analyzed in oncology clinical trials to determine their utility

The Surveillance Panel:
True to its name, the surveillance panel has been optimized with the guideline genes and 180 additional genes to allow for longitudinal analysis that monitors tumor burden (TMB) and minimal residual disease (MRD).

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Illumina TSO500

The TruSight Oncology (TSO) 500 Panel: The TSO panel is designed for the SNV, Indel, CNV and fusion analysis of 523 oncology related genes making it a great biomarker discovery tool. It also analyzes Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI).

The TruSight Tumor 170 Panel: Comprehensive next-generation sequencing (NGS) assay that targets DNA and RNA variants from the same FFPE sample.

Comprehensive Services

Library Preparation

  • Optimized extraction protocols for nearly any sample type
  • Optimized protocols for working with ultra-low amounts of nucleic acid
  • Dual concurrent RNA-DNA extraction from challenging sample types such as FFPE tissue
  • Exosome Capture

Sequencing Modalities

  • RNA Seq
  • Exome
  • Genome
  • Oncology Panels
  • Exosome-RNASeq
  • Exosome-micro-RNASeq
  • Long Read Sequencing

Capture Technologies

  • IDT
  • Twist
  • Agilent
  • Qiagen
  • Illumina

Sequencing Panels

  • Illumina TruSight Tumor 170
  • Illumina TruSight Oncology 500
  •  Solid Tumor FFPE TSO500
  • Plasma ctDNA TSO500
  • TSO500 Solid Tumor NGS Services
  • TSO500 ctDNA NGS Services for liquid biopsies
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CUSTOM Panel Development

ResearchDx has the experience and expertise to develop and validate your custom NGS assay. ResearchDx can optimally design Small (<20 targets) medium (20-200 targets) or Large (200-22000 targets) target panels using a range of technologies including both hybrid capture and amplicon.

Need a custom panel, please Schedule a consultation to discuss your Next Generation Sequencing Service needs

EXO-NET® Pan-Exosome RNA and micro-RNA Analysis

EXO-NET® Pan-Exosome Capture is an immunoaffinity magnetic bead-based isolation system,  for exosome isolation from plasma, serum, urine, saliva and cell-conditioned medium.

ResearchDx has validated Exosome solutions including:

  • Exosome-RNASeq
  • Exosome-microRNASeq
  • Exosome-Total RNA
  • Exosome Total DNA

EXO-NET is the highest-efficiency exosome isolation solution available

ResearchDx is a certified provider of EXO-NET exosome sequencing services.
Please contact us to learn more.

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Flexible Bioinformatics Analysis and Data Storage

WetLab Only: Raw BCL and FASTQ file output WetLab and QC Reporting: Standard application-specific and quality report outputs (BCL, FASTQ, aligned BAM files and sequencing QC reports. Variant Reporting Standard output plus variant calling (VCF, g-VCF). Full Clinical Reports including curated genomic interpretation reports. Additional custom reporting options including Ingenuity Variant Analysis (Qiagen) consolidated variant reports as well as options for genomic variant annotation are available.

Our CAP/CLIA-certified lab, PacificDx offers state-of-the-art facilities and expertise to meet your immediate clinical and pre-clinical needs for high-quality clinical and biopharmaceutical testing services.
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